Molecular Formula | C37H45F7N10O10 |
In vitro study | Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT 2A , 5-HT 2C , melanocortin MC4, MC5 and bombesin. |
biological activity | Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant, has the potential for rapid onset of action. Nemifitide diTFA is a peptide analog of melanocyte inhibitory factor (MIF). Nemifitide diTFA can cross the blood-brain barrier. |
Animal Model: | Male Flinders Sensitive Line (FSL) rat weighing 280-320 g |
Dosage: | 0.3 mg/kg |
Administration: | IP; daily; for 14 days |
Result: | Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect. |